Vectored immunoprophylaxis: an emerging adjunct to traditional vaccination

Table 1 Infections for which vectored immunoprophylaxis has been tested

	Vector	Animal models	References
HIV (or SHIV)	Plasmid, lentivirus, rAAV2, scAAV2, rAAV8, scAAV1,	BALB/c mice, NSG mice, Rag-1 mice, Rhesus macaques	[12, 23–26, 29, 32, 33]
hepatitis C virus	rAAV9	Rosa26-Fluc mice	[16]
Plasmodium falciparum	rAAV8	C57BL/6 mice	[15]
influenza A virus	Ad5, rAAV8, rAAV9	BALB/c mice, NSG mice, ferret, rhesus macaques	[13, 14, 21]
respiratory syncytial virus (RSV)	Ad5, rAAVrh10	BALB/c mice	[17]
Bacillus anthracis	Ad5, rAAVrh10	C57BL/6 mice	[18]
dengue virus	Plasmid	C57BL/6 mice	[19]
chikungunya virus	Plasmid	BALB/c mice	[20]

Adapted from [1]
Abbreviations: rAAV recombinant adeno-associated virus, scAAV self-complementary adeno-associated virus, Ad5 adenovirus serotype 5

ISSN: 2055-0936